Saturday, December 17, 2011

President Greets Belgian Prime Minister

07.12.2011

President of the Republic of Uzbekistan Islam Karimov has sent a congratulatory note to Elio Di Rupo on his appointment as Prime Minister of the Kingdom of Belgium.

Islam Karimov expressed conviction that Elio Di Rupo?s activities in that high-ranking position will help further enhance and reinforce Uzbek-Belgian relations built on principles of long-term partnership and mutually gainful cooperation.

Source: http://www.press-service.uz/en/news/show/main/president_greets_belgian_prime_minister/

texas judge tom brokaw maria shriver andy irons ethan zohn jeremy mayfield occupy oakland general strike

'War Horse' author makes quiet appearance in play

In this undated file photo released by HarperCollins, British author Michael Morpurgo, author of "War Horse," is shown. Morpurgo, who wrote the book the Tony Award-winning play is based on, was part of more than a dozen actors watching the auctioning-off of the horse Joey at the top of the show in New York. The author, who made a similar appearance in the London production of "War Horse" and is an extra in Steven Spielberg's movie version, didn't speak any dialogue and didn't appear again until the curtain call a few hours later. (AP Photo/HarperCollins)

In this undated file photo released by HarperCollins, British author Michael Morpurgo, author of "War Horse," is shown. Morpurgo, who wrote the book the Tony Award-winning play is based on, was part of more than a dozen actors watching the auctioning-off of the horse Joey at the top of the show in New York. The author, who made a similar appearance in the London production of "War Horse" and is an extra in Steven Spielberg's movie version, didn't speak any dialogue and didn't appear again until the curtain call a few hours later. (AP Photo/HarperCollins)

FILE - In this theater publicity image released by Lincoln Center Theater, a scene is shown from the production of "War Horse," performing at the Lincoln Center Theater in New York. Best-selling author Michael Morpurgo, who wrote the book the Tony Award-winning play is based on, was part of more than a dozen actors watching the auctioning-off of the horse Joey at the top of the show. The author, who made a similar appearance in the London production of "War Horse" and is an extra in Steven Spielberg's movie version, didn't speak any dialogue and didn't appear again until the curtain call a few hours later. (AP Photo/Lincoln Center Theater, Paul Kolnik)

NEW YORK (AP) ? Audiences at Wednesday's matinee performance of "War Horse" likely never noticed a very special actor who was making his Lincoln Center stage debut.

Best-selling author Michael Morpurgo, who wrote the book the Tony Award-winning play is based on, was part of more than a dozen actors watching the auctioning of the horse Joey at the top of the show.

The author, who made a similar crowd scene appearance in the London production of "War Horse" and was an extra in Steven Spielberg's movie version, didn't have any dialogue and didn't appear again until the curtain call a few hours later. The only hint he was there was when the auctioneer called out for "Mr. Morpurgo."

"They hide me away," the 68-year-old writer said with a smile during a backstage interview, still wearing his velvety Edwardian-era coat. "For me, it's a wonderful privilege for me to be connected to this whole way that theater works."

In some ways, Morpurgo's New York professional acting debut was more meaningful than the others: His father ? the Canadian actor Anthony van Bridge ? twice appeared at Lincoln Center in the 1960s.

Morpurgo, who has written more than 100 children's books, had come to New York after visiting the Canadian cast of "War Horse" in Toronto, which starts up in February. The chance to step where his father stepped years ago was too irresistible to turn down.

"I thought, 'I've got to go and be in the same place.' Isn't it silly?" he said. "I love full circles."

Van Bridge, a respected actor in Canada who was a fixture at the Shaw and Stratford festivals, left Morpurgo's mother after returning from World War II to find she'd rather be with another man. Morpurgo and his father eventually reunited when he was in his 20s; he now calls him a "sweet, kind man."

"War Horse" premiered at the National Theatre in November 2007. After two sold-out runs, it moved to London's West End in March 2009, where it continues to play at the New London Theatre. It opened at Lincoln Center this year and won five Tonys, including best play, and a U.S. tour will open in Los Angeles in June and travel to 19 cities, including Philadelphia, Dallas and Minneapolis.

Morpurgo, a former teacher who discovered his love of storytelling in the classroom, likes to visit each cast to talk about the roots of his best-selling 1982 children's book, which tells the story of a horse that has been enlisted to fight for the English in World War I. The show, adapted by Nick Stafford, is visually stunning, thanks to creative work by Handspring Puppet Company.

At one point during the interview, Austin Durant, who plays the auctioneer Chapman Carter, comes in to ask Morpurgo to autograph a volume of "War Horse" for his mother, Doris, as a Christmas present.

"Auctioneer, you were wonderful," Morpurgo told him.

"It was great!" said Durant, beaming. "Well played."

Morpurgo, who was Britain's third children's laureate, laughs about the incredible path his book "War Horse" has taken. When it was first published, it was largely ignored and for years never sold more than a few thousand copies a year, though his wife, Clare, thinks it is his best.

Then in 2005, Tom Morris, a director at the National Theatre, was looking for a way to create with Handspring Puppet Company a family friendly work. Morris' mother suggested "War Horse" after reading a second-hand copy.

Now it's been translated into 33 languages and has more than 500,000 copies in print.

"It's the same bloody book," he said, laughing.

___

Online: http://www.warhorseonbroadway.com

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2011-12-14-Theater-War%20Horse/id-29d16982cde0434bb6f688b09537c35d

lindsay lohan’s playboy cover leaked online kevin martin va tech shooting 2011 cj wilson coriolanus coriolanus jon corzine

Top 20 Concert Tours from Pollstar (AP)

The Top 20 Concert Tours ranks artists by average box office gross per city and includes the average ticket price for shows in North America. The previous week's ranking is in parentheses. The list is based on data provided to the trade publication Pollstar by concert promoters and venue managers.

TOP 20 CONCERT TOURS

1. (1) Cirque du Soleil - "Michael Jackson: The Immortal"; $1,924,258; $116.04.

2. (2) Taylor Swift; $1,319,188; $69.32.

3. (4) Enrique Iglesias; $806,680; $69.00.

4. (5) Journey; $680,930; $57.95.

5. (6) Foo Fighters; $647,638; $47.97.

6. (7) Keith Urban; $580,113; $61.91.

7. (9) Katy Perry; $519,795; $44.95.

8. (8) Caifanes; $500,310; $48.01.

9. (10) Jason Aldean; $497,140; $36.39.

10. (New) Furthur; $477,523; $51.92.

11. (New) Andr? Rieu; $387,193; $74.72.

12. (14) Ti?sto; $323,043; $48.38.

13. (New) Deadmau5; $320,277; $45.40.

14. (New) Duran Duran; $279,359; $71.73.

15. (15) Paul Simon; $263,320; $77.13.

16. (16) Jeff Dunham; $254,467; $47.47.

17. (New) Roger Daltrey; $240,036; $78.37.

18. (New) Judas Priest; $231,224; $51.06.

19. (17) "So You Think You Can Dance"; $206,626; $53.92.

20. (19) Ray LaMontagne; $187,656; $44.80.

For free upcoming tour information, go to http://www.pollstar.com

Source: http://us.rd.yahoo.com/dailynews/rss/movies/*http%3A//news.yahoo.com/s/ap/20111216/ap_en_mu/us_top20_concert_tours

amityville horror puss in boots the rum diary trailer the rum diary trailer nor easter nor easter st.louis cardinals

Friday, December 16, 2011

Key genetic error found in family of blood cancers

ScienceDaily (Dec. 15, 2011) ? Scientists have uncovered a critical genetic mutation in some patients with myelodysplastic syndromes -- a group of blood cancers that can progress to a fatal form of leukemia.

The research team at Washington University School of Medicine in St. Louis also found evidence that patients with the mutation are more likely to develop acute leukemia. While this finding needs to be confirmed in additional patients, the study raises the prospect that a genetic test could one day more accurately diagnose the disorder and predict the course of the disease.

The research is available online in Nature Genetics.

The scientists discovered the mutation in a gene known as U2AF1 when they sequenced the entire genome of a 65-year old man with myelodysplastic syndrome that had progressed to leukemia and compared it with the genome of his tumor cells. They also found the genetic error in other patients with myelodysplastic syndromes, an indication of the mutation's significance.

"The mutation in this gene was not on anyone's radar screen," says senior author and hematologist/oncologist Matthew Walter, MD, assistant professor of medicine. "In many cases, the diagnosis of myelodysplastic syndromes is unclear because there isn't a straightforward diagnostic test. By understanding at the genetic level what is contributing to this disease, we hope to eventually improve the diagnosis and treatment of this disorder."

Myelodysplastic syndromes are a difficult-to-treat family of blood cancers that occur when blood cells in the bone marrow don't mature properly. About 28,000 Americans are diagnosed with the disorder each year, most of them over age 60. Drugs are available to treat the disease, but none can cure it.

In about 30 percent of cases, the disorder progresses to a form of acute myeloid leukemia that usually is fatal because chemotherapy drugs are not effective in these patients. Doctors currently assess the likelihood that a patient with myelodysplastic syndrome will develop leukemia by looking at the chromosomes in the tumor cells to determine the extent to which they have broken apart and rearranged themselves, an indicator of the severity of the disease.

"There are chromosomal patterns that indicate high risk and low risk, but the current methods to determine prognosis aren't perfect," says first author Timothy Graubert, MD, associate professor of medicine, who specializes in treating patients with myelodysplastic syndromes.

After identifying the U2AF1 mutation in three patients through whole-genome sequencing, the researchers scoured the gene for the mutation in another 150 patients with myelodysplastic syndromes. They identified the mutation in 13, or nearly 9 percent. The mutations were acquired during development of myelodysplastic syndromes because they were not present in normal cells obtained from each patient.

Patients were almost three times as likely to develop leukemia if they had a mutation in the U2AF1 gene. The disorder progressed to leukemia in 15.2 percent of patients with the mutation, compared with 5.8 percent of those without the genetic error.

The most common mutation results in a single letter change in the DNA at a precise location in the U2AF1 gene. Patients with the genetic error were most likely to have the amino acids phenylalanine or tyrosine substituted for a serine. The researchers say that the mutation by itself does not cause myelodysplastic syndromes but appears to be an early event in the course of the disease.

Normally, the U2AF1 gene makes a protein involved in splicing RNA, a sister molecule of DNA that carries the instructions for building proteins. Splicing brings together different sections of RNA necessary to make a protein and discards those sections that are not needed. The mutated version of the gene still produces a protein, but its splicing activity is altered, which may be important for the development of some cancers.

The new research, funded in part by a federal stimulus grant, adds to a flurry of new findings about the genetic basis of myelodysplastic syndromes. Recent studies in Nature and the New England Journal of Medicine, along with the current study, have identified mutations in a total of eight genes involved in RNA splicing in patients with the disorder.

"Together, these findings are a real game-changer," Graubert says. "A mutation in any one of these eight genes occurs in up to 50 percent of patients with myelodysplastic syndromes. Because these changes are so common, we think there are likely to be implications for improving the diagnosis of the disorder and finding new therapeutic options."

Whole-genome sequencing for cancer was pioneered by scientists at Washington University School of Medicine and the university's Genome Institute, including Richard Wilson, PhD; Elaine Mardis, PhD; Timothy Ley, MD; and Li Ding, PhD, all of whom are co-authors of the study. The new research builds on their work to find novel mutations in cancer by looking across a patient's entire genome.

The research was supported by the National Institutes of Health (NIH) and a Howard Hughes Medical Institute Physician-Scientist Early Career Award.

Recommend this story on Facebook, Twitter,
and Google +1:

Other bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Washington University School of Medicine. The original article was written by Caroline Arbanas.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Timothy A Graubert, Dong Shen, Li Ding, Theresa Okeyo-Owuor, Cara L Lunn, Jin Shao, Kilannin Krysiak, Christopher C Harris, Daniel C Koboldt, David E Larson, Michael D McLellan, David J Dooling, Rachel M Abbott, Robert S Fulton, Heather Schmidt, Joelle Kalicki-Veizer, Michelle O'Laughlin, Marcus Grillot, Jack Baty, Sharon Heath, John L Frater, Talat Nasim, Daniel C Link, Michael H Tomasson, Peter Westervelt, John F DiPersio, Elaine R Mardis, Timothy J Ley, Richard K Wilson, Matthew J Walter. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nature Genetics, 2011; DOI: 10.1038/ng.1031

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/12/111215113519.htm

country music awards new earth light year light year michelle rounds michelle rounds cabin in the woods

Antonio Lucio: The Importance of Self Advocacy

Self-advocacy and thirst for feedback, are essential qualities for career management and life - from the classroom to the boardroom.

I consider myself to be a lifelong student of leadership and my search for learning sometimes takes me to the most unusual places. Last week it was at a parent teacher conference for my ten year old daughter Carolina. Her teachers gave me a full report on her progress and then spent time talking about two skills the school believed to be critical in the development of lifetime learners: self advocacy and a thirst for constructive feedback. Carolina was doing very good at school. She was a great contributor to class discussion and was kind to her classmates. She was great at receiving feedback and following instructions, but she needed to become a better self advocate with teachers and other students. As I was preparing to have a great conversation with my daughter, it struck me, self-advocacy and thirst for feedback, are essential qualities for career management and life.

A lot has been written and said about the career development journey; about what people should expect from the company they work for and what they should own. It is true that there are companies that are more structured in the way they manage their employee's career. But one principle is consistent whether you are working for structured career development companies like GE, or a start up. Career development is a two-way street. There needs to be a marriage between the opportunities that a company can provide and the ambitions, aspirations and capabilities that the employee owns. It sounds rather obvious but there is one factor that many people miss. In this journey, there are huge advantages for those who take charge and decide to own and drive their side of the street. They are the people who know how to passionately advocate for their development and have an insatiable thirst for feedback.

Self advocacy is the ability to say what you need, want and hope for in life. It is the courage to express how you feel in constructive ways. It is having the humility to ask obvious questions and admit mistakes. It is making the commitment to learn and improve through actions. It is about standing up for yourself and others in the face of injustice. Self-advocacy is a skill that will open the door to transformational conversations, build self-confidence and enable career opportunities.Early in a career, self-advocacy helps gather information about how things get done: what process to follow, the right people to get involved, what pitfalls to avoid. Later in life, self-advocacy also helps individual present their work and the work of their team with conviction and purpose when projects compete for scarce resources. Finally, self-advocacy, enables individuals to focus the efforts required to succeed in the position they are in to attain the position where they want to be in the future.

Many people take a passive role in their career management, waiting for the company development process to lift them up or banking on their manager's ability to decode unrevealed career aspirations through perceived actions, behaviors and abilities. But that may not be enough. People change their minds; or through information a new path is identified; or life throws a curve ball. It is sometimes difficult for a manager to keep track of everything that happens in all employees' lives and minds. Self-advocacy will facilitate fluid and candid conversations that will insure alignment between company mission and employee aspirations at any given point in time.

If self-advocacy is about speaking up for what we need and want, seeking feedback is about keeping score. Feedback is what enables us to confirm and repeat what worked and amend or avoid what did not. It is not for the tame at heart, but embracing the discipline may be the most efficient and effective way to manage a career. Beware of what you do not know because it can kill you. What you know, as bad as it may sometimes be, you can always deal with. Employees, regardless of their rank or company culture should request it, first because it will accelerate their learning process and secondly because it will show their commitment to constant improvement.

I was reminded of the power of seeking feedback recently. After delivering a flawless presentation to the Association of National Advertisers, Facebook COO, Sheryl Sandberg, ran into me in a hallway. I have known Sheryl for a while and she is a very accomplished executive with impeccable academics credentials as well as key leadership roles in the Treasury Department, Google and Facebook on her resume. After a warm welcome her first words were: "Antonio, give me feedback. What can I improve next time?" I was caught off guard by the question. "Sheryl , you did great." She pushed back: "Please, think about it and send me a note with your comments. It is the way I get better."

If someone as successful as Sheryl Sandberg can leverage the power of feedback, perhaps we all should as well. Needless to say, I told my daughter Carolina the Sheryl story that night.

?

Source: http://www.huffingtonpost.com/antonio-lucio/the-importance-of-self-ad_b_1147035.html

florida state football florida state football fsu football fsu football do a barrelroll bérénice marlohe bérénice marlohe

Wednesday, December 7, 2011

Downgrade threat, Geithner push EU to agree plan

US Treasury Secretary Timothy Geithner and his German counterpart Finance Minister Wolfgang Schaeuble, right, brief the media after a meeting at the finance ministry in Berlin, Tuesday, Dec. 6, 2011. (AP Photo/Markus Schreiber)

US Treasury Secretary Timothy Geithner and his German counterpart Finance Minister Wolfgang Schaeuble, right, brief the media after a meeting at the finance ministry in Berlin, Tuesday, Dec. 6, 2011. (AP Photo/Markus Schreiber)

US Treasury Secretary Timothy Geithner attends a press conference with his German counterpart Finance Minister Wolfgang Schaeuble after a meeting at the finance ministry in Berlin, Tuesday, Dec. 6, 2011. (AP Photo/Markus Schreiber)

German Chancellor Angela Merkel reacts during a news conference with Afghan President Afghan President Hamid Karzai where she has to answers questions about the the news that Standard & Poor's is examining the credit rating of 15 eurozone countries for a possible downgrade, at the chancellery in Berlin, Tuesday, Dec. 6, 2011. Merkel told reporters Tuesday that 'what a rating agency does is the responsibility of the rating agency' but that European leaders would plot a course to 'regain confidence' when they meet later this week. (AP Photo/Markus Schreiber)

US Treasury Secretary Timothy Geithner, center, leaves the European Central Bank after a meeting with officials of the ECB in Frankfurt, Germany, Tuesday, Dec. 6, 2011. Geithner will travel to Berlin later the day to meet with German Finance Minister Wolfgang Schaeuble. (AP Photo/Michael Probst)

German Chancellor Angela Merkel reacts during a news conference with Afghan President Afghan President Hamid Karzai where she has to answers questions about the the news that Standard & Poor's is examining the credit rating of 15 eurozone countries for a possible downgrade, at the chancellery in Berlin, Tuesday, Dec. 6, 2011. Merkel told reporters Tuesday that 'what a rating agency does is the responsibility of the rating agency' but that European leaders would plot a course to 'regain confidence' when they meet later this week. (AP Photo/Markus Schreiber)

BERLIN (AP) ? European nations were pressed Tuesday by a credit downgrade threat and the U.S. Treasury chief to deliver on markets' huge hopes for a solution to the 2-year-old financial crisis engulfing the continent.

Germany and France downplayed Standard & Poor's warnings to downgrade 15 eurozone nations and Europe's bailout fund. But a downgrade of their AAA ratings would complicate their efforts to restore investor confidence in Europe.

Loans from the bailout fund have rescued Ireland, Portugal and Greece, but if the fund loses its own AAA rating, it could have to charge higher rates to rescue countries in the future, making it tougher for them to recover.

That heaps more uncertainty on the fund, which many had already dismissed as too small to bail out a country like Italy. Help from abroad also seemed unlikely ? U.S. Treasury Secretary Timothy Geithner said the Federal Reserve has no plans to give money to the International Monetary Fund to bolster Europe's bailout fund.

He is on a three-day tour of Europe to express U.S. support but also, many say, to impress on regional leaders the need to get their crisis plan right. A break-up of the eurozone would have dire consequences for the global economy.

German Finance Minister Wolfgang Schaeuble said the S&P ratings warning may not be all bad, since it could spur action at a European summit this week billed as the meeting "to save the euro."

"We take this assessment as further reassurance to do everything to achieve a good result on December 9th," Schaeuble said in Vienna.

The markets also largely shrugged off the news, perhaps because they had long ago resigned themselves to the fact that the eurozone's credit ratings might be lowered. Investors have recently been charging even big countries like France more to borrow, suggesting they did not quite believe in the AAA ratings.

S&P's first warning ? on the 15 countries' ratings ? came Monday, just hours after German Chancellor Angela Merkel and French President Nicolas Sarkozy urged changes to the European Union treaty that would centralize decision-making on spending and borrowing for the 17 countries that use the euro.

While those reforms will likely take months or years to implement, European leaders hope they will impress the European Central Bank or the International Monetary Fund enough to persuade one or both to step into the breach quickly with more financial aid.

While there is a sense that leaders are simply scrambling to come up with the formula that induces the ECB to act, Moritz Kraemer, S&P's head of sovereign ratings for Europe, cautioned that ECB action would not in itself save the AAA ratings. He told reporters Tuesday that a credible plan to solve the crisis was also needed.

The German and French leaders shot back Tuesday that they had just unveiled one, and that the agency had jumped the gun in putting the eurozone on notice.

"What strikes me is the time-lag of this announcement," French Foreign Minister Alain Juppe told RTL radio. Merkel and Sarkozy's proposals are "exactly the response to one of the major questions from the ratings agency, which talks about insufficient European economic governance."

While it's true that S&P had already made its decision by Monday, when it warned leaders of it, the contents of Sarkozy and Merkel's proposals later that afternoon couldn't have been that surprising to analysts at S&P. They included introducing an automatic penalty for any government that allows its deficit to exceed 3 percent of GDP; requiring countries to promise to balance their budgets; pledging that any future bailouts would not require private bond investors to absorb a part of the costs, as was the case for the Greek bailout; and reiterating a promise not to criticize the ECB.

Those are mostly a rehash of ideas that had already been floated and, in fact, Germany's inclusion on the list of countries that could be downgraded indicates S&P was already anticipating them: Berlin's bonds are considered some of the safest in the world, the German economy has been praised for maintaining modest growth even among dire circumstances. Only the prospect of further tying Germany to weaker countries would make its bonds more suspect.

Kraemer also underscored that the warning targeted all of the eurozone countries ? with the exception of two whose bonds are already rated very low ? because the agency is concerned about a paralysis in European decision-making, which cripples all of the economies, no matter how robust.

At a press conference alongside Schaeuble in Berlin, Geithner said he is "very encouraged" by the reforms taken so far by European nations. He is on a three-day trip to Germany, France and Italy in a show of support for key countries grappling with the financial crisis.

Geithner will next go to France, where he plans meetings with Sarkozy, and also with incoming Spanish Prime Minister Mariano Rajoy who will be attending a meeting in Marsailles, then to Milan, Italy, for talks with new Italian premier Mario Monti.

He said he was "very encouraged" by reform steps taken by European nations.

"I am here in Europe to emphasize how important it is for the United States and the global economy as a whole that Germany and France succeed, along side the other nations, in building a stronger Europe," Geithner said.

___

Kirsten Grieshaber and Martin Crutsinger in Berlin, David Stringer in London, Raf Casert and Gabriele Steinhauser in Brussels contributed to this story.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2011-12-06-EU-Europe-Financial-Crisis/id-590d6e09ad124829817ba0412d083fd1

great pumpkin charlie brown the strangers all hallows eve all saints day all saints day bernard madoff dallas cowboys